Introduction for National Cholesterol Month

Introduction for National Cholesterol Month.

Articles in this series • Fisher EA. Introduction for National Cholesterol Month. Arterioscler Thromb Vasc Biol. 2011;31:1939–1940. • Nakajima K, Yamashita T, Kita T, Takeda M, Sasaki N, Kasahara K, Shinohara M, Rikitake Y, Ishida T, Yokoyama M, Hirata K-i. Orally administered eicosapentaenoic acid induces rapid regression of atherosclerosis via modulating the phenotype of dendritic cells in LD...

National Cholesterol Awareness Month Membrane Cholesterol Is a Biomechanical Regulator of Neutrophil Adhesion

Objective—The purpose of this study was to evaluate the role of membrane cholesterol on human neutrophil and HL-60 biomechanics, capture, rolling, and arrest to P-selectin– or IL-1–activated endothelium. Methods and Results—Methyl-cyclodextrin (M CD) removed up to 73% and 45% of membrane cholesterol from HL-60 cells and neutrophils, whereas M CD/cholesterol complexes resulted in maximum enrichm...

National Cholesterol Awareness Month Nevirapine Increases High-Density Lipoprotein Cholesterol Concentration by Stimulation of Apolipoprotein A-I Production

Objective—The purpose of this study was to investigate the mechanism by which the nonnucleoside reverse transcriptase inhibitor (NNRTI) nevirapine (NVP) increases high-density lipoprotein cholesterol (HDLc) in treatment-experienced human immunodeficiency virus-1 (HIV-1)–infected patients. Methods and Results—Twelve HIV-1 infected patients, with stably suppressed HIV-1 viral load using AZT/3TC/ ...

National Cholesterol Awareness Month The ATF6-Met[67]Val Substitution Is Associated With Increased Plasma Cholesterol Levels

National Cholesterol Awareness Month Interrelationships Among HDL Metabolism, Aging, and Atherosclerosis

HDL plasma concentrations decline with age in prospective studies. Decline in HDL concentration and function may occur secondary because of hormonal changes, inflammatory processes, and diabetes mellitus. Beyond these effects specific aging processes may be involved. Replicative aging, the telomere-driven loss of divisional capacity, is a species-specific aging mechanism that may decrease HDL c...